S(-)-BAY K 8644
Bay-K-8644 ((S)-(-)-)
CAS: 98625-26-4
Molecular Formula: C16H15F3N2O4
S(-)-BAY K 8644 - Names and Identifiers
S(-)-BAY K 8644 - Physico-chemical Properties
| Molecular Formula | C16H15F3N2O4 |
| Molar Mass | 356.3 |
| Solubility | 10 mM in DMSO |
| Appearance | solid |
| Color | yellow |
| Storage Condition | 2-8°C |
| In vitro study | (±)-Bay K 8644, a conventional racemic mixture of Bay K 8644, is widely used as an L-type Ca 2+ channel agonist. Each optical isomer possesses opposite effects on IBa (R(+)-Bay K 8644 as an antagonist and (S)-(-)-Bay-K-8644 as an agonist. (S)-(-)-Bay-K-8644 can prevent the inhibitory actions of two distinct cyclic nucleotide pathways on I Ba in gastric myocytes of the guinea pig antrum. The Ca 2+ channel activity is enhanced by 3–30 μM (S)-(-)-Bay-K-8644 an agonist of L-type Ca 2+ channels. The interactions of two Ca 2+ channel activators (S)-(-)-Bay-K-8644 and FPL 64176 is examined on smooth muscle L-type Ca 2+ channels. FPL 64176 (300 nM) causes a sustained contraction of rat tail artery strips. This contractile response is inhibited by approximately 70% by (S)-(-)-Bay-K-8644 (EC 50 =14 nM). (S)-(-)-Bay-K-8644 (100 nM) increases whole-cell Ca 2+ currents in A7r5 smooth muscle cells but effectively blocks further stimulation by 1 μM FPL 64176. |
S(-)-BAY K 8644 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/38 - Irritating to eyes and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
S(-)-BAY K 8644 - Introduction
Bay-K-8644 ((S)-()-) is a calcium channel agonist with the chemical name (R)-4-(R)-1,4-dihydro-2, 6-dimethy-3, 5-xridine-dicarylate. It is a compound with a chiral structure, commonly the (S)-(-)-enantiomer.
Bay-K-8644 is a highly selective dihydrodipicolinic acid calcium channel agonist. It can enhance the opening of L-type calcium channels on the cell membrane, thereby increasing the intracellular calcium ion concentration. Therefore, it is widely used as an experimental tool to study related physiological processes such as neurotransmitter release, myocardial contraction and vasoconstriction.
The method for preparing Bay-K-8644 is relatively complicated and generally includes multi-step reactions. The important step is to react 2-butyl imidazole and propargyl amine to obtain 4-(4-dihydro-2)-1,4-dihydro-2,6-dimethyl-3,5-pyridine-dicarboxylic acid methyl ester, and then the final product is obtained by addition reaction with the substrate generated by the reaction.
Regarding safety information, Bay-K-8644 need to be careful in some laboratory applications and follow laboratory safety procedures. It may be irritating to the eyes, skin and respiratory tract, so direct contact should be avoided when used. At the same time, it may be harmful to the environment, and appropriate disposal measures should be taken to avoid its entry into water sources and soil. Gloves, masks and goggles should be worn during use to ensure a well-ventilated laboratory environment.
Bay-K-8644 is a highly selective dihydrodipicolinic acid calcium channel agonist. It can enhance the opening of L-type calcium channels on the cell membrane, thereby increasing the intracellular calcium ion concentration. Therefore, it is widely used as an experimental tool to study related physiological processes such as neurotransmitter release, myocardial contraction and vasoconstriction.
The method for preparing Bay-K-8644 is relatively complicated and generally includes multi-step reactions. The important step is to react 2-butyl imidazole and propargyl amine to obtain 4-(4-dihydro-2)-1,4-dihydro-2,6-dimethyl-3,5-pyridine-dicarboxylic acid methyl ester, and then the final product is obtained by addition reaction with the substrate generated by the reaction.
Regarding safety information, Bay-K-8644 need to be careful in some laboratory applications and follow laboratory safety procedures. It may be irritating to the eyes, skin and respiratory tract, so direct contact should be avoided when used. At the same time, it may be harmful to the environment, and appropriate disposal measures should be taken to avoid its entry into water sources and soil. Gloves, masks and goggles should be worn during use to ensure a well-ventilated laboratory environment.
Last Update：2024-04-09 21:11:58
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Product Name: Bay-K-8644 ((S)-(-)-) Visit Supplier Webpage Request for quotation
CAS: 98625-26-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 98625-26-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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